Tsunade is a fair-skinned and tall woman with champagne blonde hair and pine brown eyes. She has a amethyst coloured diamond shaped sticker on her forehead. She also has straight hair that creates bangs on either side of her forehead.
She usually wears a grey kimono-type top with no sleeves and a green haori over it with a dark bluish-grey obi that matches her pans. Her finger nails and toe nails are observed to be cherru red in color. She also wears baby pink lipstick.
Although she looks like a young woman, she is actually 54 years old, something which Lee and the others tend to make fun of her time to time.
Tsunade can be described as a tsundere. Her personality is very much like that of Sakura's.
Tsunade is considered to be the most powerful kunoichi in the world and the greatest medical-nin of all time.